2-C-metil-D-eritritol 4-fosfat sitidiltransferaza sahifasining manbasini koʻrish

[[Fermentlar|Enzimologiyada]] '''2-C-metil-D-eritritol 4-fosfat sitidiltransferaza''' (EC)) [[Kimyoviy reaksiya|kimyoviy reaksiyani]] [[Kataliz|katalizlovchi]] [[Fermentlar|ferment]] hisoblanadi.

: 2-C-metil-D-eritritol 4-fosfat + CTP <math>\rightleftharpoons</math> difosfat + 4-(sitidin 5'-difosfo)-2-C-metil-D-eritritol
<gallery>
Fayl:MEP.png|[[2-C-methylerythritol 4-phosphate|2-C-metileritritol 4-fosfat]]
Fayl:CTP chemical structure.png|[[Cytidine triphosphate|Sitidin trifosfat]]
Fayl:4-diphosphocytidyl-2-C-methylerythritol.png|[[4-Diphosphocytidyl-2-C-methylerythritol|4-difosfositidil-2-C-metileritritol (CDP-ME)]]
</gallery>Shunday qilib, ushbu fermentning ikkita substrati CTP va 2-C-metil-D-eritritol 4-fosfat hisoblanadi, uning ikkita oxirgi mahsuloti difosfat va 4-difosfositidil-2-C-metileriitritoldir.

Ushbu ferment transferazlar oilasiga, xususan, fosfor oʻz ichiga olgan [[Nukleotidlar|nukleotid]] guruhlarini (nukleotidiltransferaza) turkumiga tegishli.

Bu ferment izoprenoid biosintezi va stevenozimda ishtirok etadi. MEP yoʻlining uchinchi bosqichini [[Kataliz|katalizlaydi]] ; CTP va MEP (2C-metil-D-eritritol 4-fosfat) dan CDP-ME (4-difosfositidil-2C-metil-D-eritritol) hosil boʻlishi<ref name="pmid10841550">{{Cite journal|title=Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=97|issue=12|pages=6451–6|date=June 2000|pmid=10841550|pmc=18623|doi=10.1073/pnas.97.12.6451|bibcode=2000PNAS...97.6451R}}</ref>. Izoprenoid infektsiya yoʻliga qarshi dori ishlab chiqish uchun ham keyinchalik qoʻllash maqsad qilingan<ref name="pmid17081012">{{Cite journal|title=Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods|journal=J. Org. Chem.|volume=71|issue=23|pages=8824–34|date=November 2006|pmid=17081012|doi=10.1021/jo061466o}}</ref><ref name="pmid17921290">{{Cite journal|title=Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development|journal=J. Bacteriol.|volume=189|issue=24|pages=8922–7|date=December 2007|pmid=17921290|pmc=2168624|doi=10.1128/JB.00925-07}}</ref>.

== Nomlanishi ==
Ushbu ferment sinfining tizimli nomi '''CTP: 2-C-metil-D-eritritol 4-fosfat sitidiltransferazadir''' . Bu ferment deb ham ataladi.

* MEP sitidiltransferaza
* CDP-ME sintetaza
Bu odatda IspD deb qisqartiriladi. Bundan tashqari, ochiq mutoolalarda YgbP deb ham yuritiladi.

== Strukturaviy tadqiqotlar ==
''E. coli'' 2-C-metil-D-eritritol 4-fosfat 1I52, 1INI & 1INJ ning kristall tuzilishi, Richard va boshq. (2001), MEP yoʻlida ishtirok etgan ferment uchun birinchi boʻldi.

2010-yil fevral holatiga koʻra, ushbu fermentlar sinfi uchun PDB qoʻshilish kodlari 1H3M, 1VGT, 1VGU, 1VGZ, 1VPA, 1VGW, 1W55, 1W57, 1W77, 2PX7 va 2VSI 2VSH 13 ta boshqa [[Oqsilning uchlamchi strukturasi|tuzilmalar]] hal 3F1C .

== Manbalar ==
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== Qoʻshimcha adabiyotlar ==
{{Refbegin}}
* {{Cite journal|year=2001|title=Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.|journal=Nature Structural & Molecular Biology|volume=8|pages=641&ndash;8|pmid=11427897|doi=10.1038/89691|issue=7}}
* {{Cite journal|last=Kuzuyama T|last2=Takagi M|last3=Kaneda K|last4=Dairi T|last5=Seto H|year=2000|title=Formation of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway|journal=Tetrahedron Lett.|volume=41|issue=50|pages=703&ndash;706|doi=10.1016/S0040-4039(99)02143-7}}
* {{Cite journal|display-authors=etal|year=1999|title=Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of ''Escherichia coli'' catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol|journal=Proc. Natl. Acad. Sci. USA|volume=96|pages=11758&ndash;63|pmid=10518523|doi=10.1073/pnas.96.21.11758|issue=21|pmc=18359}}
{{Refend}}



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